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Korean RCT (2021) — 105 healthy overweight Korean adults supplemented with chlorogenic acid isomers (equivalent to GCE components) for 12 weeks showed reduced body fat mass by 1.4 kg and visceral fat area by 12.5 cm² versus placebo [28]

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Nevertheless, it remains unclear how PDGFα-signaling impacts microgliosis and astrogliosis in these transgenic mice (hPDGFα-GFAP, PDGFαR +/−), since it is known that astrocytes also express PDGFαR and respond to PDGFα (Besnard et al., 1987