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The genes activated by Nrf2 include the two subunits of glutamate cysteine ligase (GCL), the rate-limiting enzyme in glutathione biosynthesis, as well as glutathione reductase, glutathione S-transferases, and glutathione peroxidase

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This quantitative understanding is now driving the development of pathway-specific inhibitors, such as PKC-β selective antagonists, SGLT2 inhibitors, and glyoxalase-1, which have shown promise in preclinical models for breaking this cycle without globally suppressing physiologically important ROS signaling -Figure 3 (Oliveira et al., 2023