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In addition, overproduction of systemic cytokines, particularly IL-2, IFN-γ, GM-CSF, and TNF-α, triggers macrophage activation (i.e., MAS) and erythro-phagocytosis (i.e., HLH), resulting in anemia, 94,95 as well as causes perturbation of coagulation and vascular hemostasis, resulting in capillary leak syndrome, thrombosis, 96 and DIC