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First-generation PSs, most notably Photofrin ® (porfimer sodium/dihematoporphyrin ether) administered either topically or intravenously, achieved one-year complete remission (CR) rates of 72.7% to 96.1% across CIN grades 1–3 following irradiation with 630 nm light at energy densities of 100–140 J/cm² (44–46)

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doi: 10.1016/j.lfs.2020.117359 157