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In hypertensive states, mitochondria generate excessive ROS due to electron transport chain (ETC) disruption, particularly at complexes I and III, coupled with reduced antioxidant defenses (e.g., Mn-SOD) (Tábara et al., 2025)

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Tirzepatide produces greater average weight loss (20.2% vs 13.7% body weight at 15 months), which affects cost-effectiveness calculations

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