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monocytogenes was exposed to 640µM 4-HNE for 20 minutes, the four genes tested ( clpC, clpE, dnaK, groES ) were significantly induced compared to vehicle controls (Fig 2D)

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Potential implications of the new pharmacotherapies on obesity management The mean WL in clinical trials with the most efficacious new obesity pharmacotherapies ranges between 15% and 25% at 1 year (and it may be even higher for some agents that have not reached weight plateau at study completion)