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does the latter relapse refer to non-drug relapse?” Response: We have replaced this sentence with: “Enhanced D1 receptor signaling would also explain why addicts are more prone to relapse when stressed or hungry, both conditions that augment ghrelin secretion and sensitivity.” “There are many abbreviations used in the text that are not found in the abbreviation list (given abbreviations are not always defined upon first use, it is critical that they be defined somewhere).” Response: All abbreviations have been added to the abbreviations list, and each abbreviation is now written out in full when first used

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Mast cells are originated from pluripotent progenitor cells of the bone marrow, and mature under the influence of the c-kit ligand and stem cell factor in the presence of other distinct growth factors provided by the microenvironment of the tissue where they are destined to reside