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Possible causes of 5‐fluorouracil‐induced renal damage include the overexpression of nuclear factor kappa B (NF‐κB), renal‐inducible nitric oxide synthase, and cytokines, as well as the activation of the apoptotic cascade via the upregulation of caspase‐3

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For example, for a patient with a recent history of a Deep Venous Thrombosis (DVT) on anticoagulation medication, a primary care team must often balance whether or not to hold the patient's anticoagulation in order for the patient to receive a colonoscopy (where removal of a polyp while the patient is on anticoagulation can lead to excessive bleeding)