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Although RNS play a crucial role in antimicrobial defense, these mechanisms also contribute to host tissue and cell damage, leading to outcomes such as endoplasmic reticulum stress, mitochondrial dysfunction, cell death, and vascular impairment ( Figure 1C )

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However, despite the low carriage rate, in some Asian countries, the mortality rate of IMD is high due to weak surveillance and/or the lack of routine vaccination (Wang et al., 2019)