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147,148 These interactions keep the substrate backbone low and tight against the enzyme surface

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In summary, PPP supplies, via ribose-5-phosphate through the action of PRPP synthase enzyme, the main metabolic substrate of the purine salvage pathway, namely phosphoribosyl-1-pyrophosphatase, while glycolysis supplies specific enzymes, such as phosphofructokinase and phosphoglycerate kinase, able to convert the ADP into ATP [85]