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The mechanism of Th17 production involves indole-amine 2,3­dioxygenase (IDO), since in murine and human CF dysfunctional IDO activity correlated with imbalanced Th17/Treg cell responses to Aspergillus fumigatus , that was restored by genetic recue of IDO production as represented in Figures 1 and 2 [39]

which allows it to support neurotransmitter activity and promote healthy brain function