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Generation of iPSC-derived kidney organoids recapitulating human Fabry nephropathy To generate Fabry kidney organoids, GLA-mutant human iPSCs were differentiated into kidney organoids using an adherent cell culture protocol 15,16

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When telomeres reach a critical length, they can no longer bind sufficient telomere-capping proteins, exposing chromosome ends that activate DNA damage response (DDR) pathways [1]