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Parkinson’s risk factors can be grouped as follows: Environmental factors (pesticides, chemicals, heavy metals) Gut microbiome changes (lack of vitamins, gut-brain axis inflammation, microplastics) Co-morbid conditions (circadian or sleep disorders, head trauma, kidney dysfunction, viral infections) Environmental factors combine with genetic susceptibility in Parkinson’s Disease: A number of environmental and lifestyle factors have been identified as increasing the relative risk of Parkinson’s