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Peroxynitrite anion is structurally similar to phosphate anion, so that the extreme vulnerability of PTPs to peroxynitrite-mediated inactivation is consistent with attraction of peroxynitrite to the active site of the enzyme and subsequent oxidation of this essential cysteine (1254)

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Moreover, different nutrients and vitamins, including some that participate in one-carbon metabolism, have been replaced in randomized, controlled trials in patients with MASH with inconsistent results [28-31]