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Toxic Overload and Depression: Elevated SAH and Glutathione

Smad3 occupancy at specific DNA loci (COL1A1 and ADAMTSL2) in TGFβ-treated LX-2 cells was assessed using chromatin immunoprecipitation sequencing (ChIP-seq) data from public datasets

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Elevated intracellular glutamine was also implicated in ferroptosis induction via glutaminolysis yet the chemical processes that lead to increased cellular oxidative stress await to be dissected 13