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In mouse models, CAR demonstrates liver-oriented accumulation and enables NIR-II CL imaging specific to HIRI-associated O 2 •− , which in turn initiates the in situ fragmentation of CAR and liberates KIR to enter the kidneys to image AKI-associated NAG via NIR-I CL

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There is some evidence that elements of the diet, such as total energy and macronutrient content, play significant roles in modulating the aging process and longevity, as well as the development of age-related diseases (i.e., cardiovascular and cerebrovascular diseases, cognitive decline and dementia, and cancer) (Figure 1) [12,13,14,15]