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A study employing a different dipeptidylpeptidase-4 inhibitor, linagliptin, following Aβ42 injection to brain ameliorated cognitive impairment, attenuated levels of Aβ42 oligomers, decreased the degree of insulin resistance (by decreasing levels of phosphorylation of the inhibitory Ser307 site on IRS-1), and diminished levels of GSK-3β and proinflammatory cytokines and, importantly, decreased levels of oxidative and nitrosative damage in hippocampus