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There has been debate regarding whether pimobendan would increase ventricular arrhythmias, increasing the rate of cardiac death, as other phosphodiesterase 3 inhibitors do in humans

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62 Although some researchers observe that microglia engulf plaques and decrease the pathology, it is also thought that they may be responsible for spreading the pathology, where activation of microglia can contribute to NI, releasing inflammatory mediators, including ROS