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Ferritin upregulation is associated with the epithelial-mesenchymal transition (EMT) and chemoresistance in glioma under hypoxic conditions, by activating the AKT/Glycogen synthase kinase-3 beta (GSK3β)/β-catenin signalling pathway (Figure 4) (Liu et al., 2020)

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In particular, we highlight the potential of estrogen receptor modulators, hormone replacement therapy (HRT), and alternative treatments in improving mental health and cognitive outcomes in menopausal women