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Classified as a selective Nicotinamide N-methyltransferase (NNMT) small-molecule inhibitor, this quaternary ammonium compound achieves around 38.4% oral bioavailability in rodent trials, an acceptable absorption rate for positively charged quinolinium derivatives that typically face poor intestinal permeability

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Persistent side effects beyond 2 weeks after a dose increase Transient nausea, mild constipation, and decreased appetite are expected and normal during the 1 to 2 weeks after each dose increase