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Growth hormone secretion tends to return to normal after weight loss indicating that low GH is a consequence, not a cause, of central obesity ( While IGF-I remains the biomarker that best reflects endogenous GH secretion, when there is a discordancy with GH and IGF-I levels, it is important for the clinician to be mindful of the associated changes in intra-portal insulin delivery to the liver when interpreting these results in the context of health and when deciding treatment regimens in disease states

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PubChem [Internet]