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1 Why Researchers Study NNMT Researchers study NNMT because its expression differs from cell to cell and across tissues, and studies have observed that it may be especially active in: 4 Skeletal muscle Connective tissue Adipocytes (fat cells) Liver tissue Certain immune cells Due to this activity, NNMT is of interest to scientists when examining: 4 Mitochondrial health Fat cell metabolism Cellular aging and metabolism Metabolic pathways Energy expenditure The evidence to date indicates that NNMT impacts nicotinamide recycling and how cells balance methyl donor availability, and experts continue to use experimental models to determine how these processes might be involved in changes in fat mass, body composition, and visceral adipose tissue