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Safety and effectiveness of Dextrose and Sodium Chloride Injections USP in pediatric patients have not been established by adequate and well-controlled studies

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The low detection accuracy of in vivo imaging, caused by interference from free iron, parallels the translational paradox seen in clinical trials of iron chelators such as deferoxamine—effective in animals but ineffective in humans—revealing that a coordinated validation system linking molecular targets, imaging evaluation, and clinical efficacy is still lacking