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GLP-1 agonists are themselves diabetes medications, so combining them with other glucose-lowering drugs requires careful medical supervision to avoid hypoglycemia

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A 2018 foundational study in diet-induced-obese male C57BL/6 mice (n=9 per cohort) treated subcutaneously for 11 days reported approximately 5.1% weight loss versus 1.4% weight gain in controls, with no significant food-intake difference