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28 When DNA repair pathways become disrupted, particularly those involving base excision repair and nucleotide excision repair, accumulated DNA damage triggers p53-mediated responses, which can induce cell cycle arrest, apoptosis, or premature differentiation of MSCs, directly contributing to the graying phenotype

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[DOI] [PMC free article] [PubMed] [Google Scholar] 122.Ayyadevara S., Dandapat A., Singh S.P., Siegel E.R., Shmookler Reis R.J., Zimniak L., Zimniak P