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Mechanistically, PL treatment increased reactive oxygen species (ROS) levels and induced ROS-mediated apoptosis in AML cells, which could be prevented by treatment with the antioxidant scavenger N -acetyl-cysteine and the pancaspase inhibitor Z-VAD(OMe)-FMK

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Building upon previous comprehensive evaluations (Pagel and Crystal, 2018), this review provides an updated, comprehensive synthesis that significantly advances previous analyses