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These somatic mtDNA mutations arise in tissues as well as in stem cell lineages with age and progressively erode mitochondrial function, generating the aging clock (Wallace 2005)

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Gauthier et al[78] (2003) also reported that impaired cell adhesion plays a role in vitiligo pathogenesis as the synthesis of extracellular matrix components by keratinocytes may be defective, the presence of focal gaps in the basement membrane and impaired formation of basement membrane