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Laboratory blood tests during that time intermittently showed toxic vacuolation and granulations present in the white cells with myelocytes present, a mild anemia with a hemoglobin of 11.5 g/dl (normal range 12-16 g/dL), hemoglobin of 34.9 (normal range 36-46%), slightly low platelet counts ranging between 116,000/ UL and 130,000/UL (normal range 140-400,000/ UL) with normal liver and kidney functions

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FOXO4 facilitates TM3 Leydig cell senescence and maintains the viability of senescent cells To further validate the role of FOXO4 in senescent Leydig cells, we silenced FoxO4 expression using siRNA prior to senescence induction