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The mean change in body weight from baseline to week 104 was −15.2% in the semaglutide group ( n = 152) versus −2.6% with placebo ( n = 152), for an estimated treatment difference of −12.6 %-points (95% confidence interval, −15.3 to −9.8
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Dry mouth with semaglutide often appears alongside other oral symptoms
lethargy and skin or coat abnormalities