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Similarly, ONCOS-102, an engineered adenovirus expressing GM-CSF, has been tested with pembrolizumab in advanced melanoma (NCT03003676), aiming to activate dendritic cells and potentiate T-cell–mediated responses

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Instead, the increase in V3 and ADP/t is likely attributable to the activation of ATP synthase or adenine nucleotide translocase (ANT)