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The potency of clinical candidate ARS-1620 (PDB: 5V9U) was improved by surface groove occupation, resulting in enhanced interactions with the KRAS G12C protein eventually leading to the development of clinically approved KRAS G12C inhibitor sotorasib (AMG 510, PDB: 6OIM) [99]
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[DOI] [PMC free article] [PubMed] [Google Scholar] 36.Kim TW, Cheon C, Ko SG