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For example, hypervitaminosis A can be caused by taking one large dose of over 200 mg of vitamin A, or chronic use of more than 10 times the recommended daily intake ( Vitamin A toxicity may lead to serious complications, such as increased spinal fluid pressure, coma, and potentially fatal organ damage ( Additionally, taking megadoses of vitamin D — more than 50,000 IU daily — over long periods can lead to high blood levels of calcium (hypercalcemia), which can lead to death ( Overdosing on other vitamins can likewise cause potentially fatal side effects, such as liver damage

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Phosphatidylcholine-based liquid crystalline nanoparticles (PC-LCNPs) significantly enhanced the oto-topical delivery of caroverine across rabbit tympanic membranes compared to elastic vesicles, highlighting the potential of nano-sized carriers for non-invasive treatment (Farrah et al., 2020)