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These proteins produced by helminths have been found to target monocytes/macrophages both in vivo and in vitro , triggering the release of IL-10 that suppresses inflammatory T cells (147, 148)

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For example, the agent may comprise 1, 2, 3, 4, 5 or more or any range therebetween (inclusive) in an amount of an agent that modulates one biomarker or more than one biomarker (e.g., 2 agents that modulate the same target listed in table 1 or table 2, one agent that modulates a target listed in table 1 and a second agent that modulates a target listed in table 2, a combination of an siRNA and an antibody agent that modulates a target listed in table 2, two sirnas that modulate a single target listed in table 1 and a combination of a single siRNA that modulates a single target listed in table 2 and an antibody agent that modulates another target listed in table 2, etc.)