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3.6 Anti-CD38/ICI combination therapy is ineffective in a variety of cancer types To assess the efficacy of combining anti-CD38 and PD1/PDL1-directed ICI in more generalizable scenario, we did a comprehensive literature search and compared the objective response rate (ORR) of small scale- and clinical trial-studies that administer either a combination of anti-CD38/ICI or ICI alone in various forms of cancer ( Table 2 )

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If you are experiencing such problems, in the first instance you should see your GP who will undertake a blood test, review your symptoms, and diagnose any deficiency, alongside any need for dietary changes, oral supplementation, or prescribed injections of vitamin B12