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In order to deliver the anti-inflammatory drug, 5-aminosalicylic acid (5-ASA), to the inflamed colon, they prepared 5-ASA-HSA NPs by a desolvation technique in which the active site for enzymatic degradation of HSA was internalized inside the NPs in order to protect it from the proteolytic enzymes in the gastrointestinal tract
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doi: 10.1016/j.intimp.2010.11.008