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Cancer Cell 25 (6), 719–734

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Nerve damage can have a single cause (e.g., traumatic compression as a result of acute crush injury or laceration as a result of transection injury), but in many cases (and almost always in the chronic course), it is a combination of reasons, such as laceration, traction, vibration, compression, ischemia, inflammation, alcoholism, metabolic (diabetes) or toxic noxae (chemotherapy), surgery, genetic causes, and deficiency in neurotropic B vitamins [1–6]