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Specifically, in clinical research, NMN has demonstrated the ability to suppress age-related weight gain, improve insulin sensitivity, and improve eye function, none of which NR has demonstrated to date.16 To be sure, NR is linked to a separate health benefit that NMN is not: specifically, it has been shown to decrease biomarkers of neurodegeneration by itself.19 NMN and NAD safety Apart from the risk of an allergic reaction — which practically any supplemental, medical, or dietary substance can cause — NMN and NAD pose little to no danger in the short term