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One study has shown that a factor V level less than 10% of normal indicated a poor prognosis (91% mortality), whereas a ratio of factor VIII to factor V of less than 30 indicated a good prognosis (100% survival).[50] Besides preventing an overdose, one way to prevent liver damage may be the use of Paradote
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In addition to complex I deficiency patients, riboflavin administration has been used in complex II deficiency patients, resulting in moderate clinical improvement, stable clinical picture, and prevented disease progression, as well as a twofold elevation in complex II activity in vitro (48)