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Furthermore, some CNS-penetrant NLRP3 inhibitors have entered phase human trials for neuroinflammatory diseases and neurodegenerative diseases, such as VTX3232, Emlenoflast, NT-0796

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In this work, we investigated two recently described non-electrophilic NRF2 activators, ADJ-310 and PRL-295, and demonstrated their efficacy in vitro and in vivo in human keratinocytes and Lepr db/db diabetic mice