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Ethacrynic acid exerts an antiproliferative effect on tumor cells and increases the cytotoxicity of several alkylating agents, such as melphalan, carmustine, mitomycin C, and nitrogen mustard
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In adults, glucuronidation and sulfation play a major role in APAP metabolism, and approximately 5% of the substrate is converted into NAPQI (Yoon et al., 2016)