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In people living with HIV (PLWH), even under virological suppression, studies report a higher frequency of mtDNA mutations than in age-matched HIV-negative individuals (111, 113)

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Bile acids absorbed in the intestine return to the liver via the portal vein, forming an efficient recycling system that cycles 6–8 times daily, with only approximately 5% excreted in feces ( As physiological detergents, bile acids are essential for the absorption of dietary fat, steroids, and fat-soluble vitamins