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For the structure of the CCK-8–CCK2R–G q –scFv16 and gastrin-17–CCK2R–G q –scFv16 complexes, the initial template of CCK2R was also from the GPCR Database, and 5-HT–G q (PDB ID: 6WHA) was used as an initial template for Gα q and Gβγ model building