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Ferroptosis The key process of ferroptosis is Fenton reaction—Fe 2+ and O 2 (or ROS, reactive oxygen species) function as strong oxidants and peroxidize PL-PUFA (phospholipid with polyunsaturated fatty acyl tail) to PL-PUFA-OOH [15] in the catalysis of POR (cytochrome p450 oxidoreductases) [16] or LOXs (lipoxygenases) [17]