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Common hypotheses point to genetic predisposition plus environmental triggers

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Acetylation modulates N-terminal autoproteolytic processing of SnCE1 The data shown above indicate lysine acetylation in wild type SnCE1 prohibits proteolytic processing, while all non-acetylated mutants, including SnCE1 Y212A and SnCE1 C256A, show proteolytic processing as visible by immunoblotting with a specific anti-SnCE1 antibody (Figs