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[DOI] [PMC free article] [PubMed] [Google Scholar] 78.Bain MA, Faull R, Fornasini G, Milne RW, Evans AM

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Indeed, the risk of late-stage failure is analogous to the one-off newly developed drugs, and sometimes the need for drug reformulations may be as costly as that for de novo drug development (Pushpakom et al., 2019