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An experiment in Drosophila showed that the periodic accumulation and degradation of core clock protein depended on UPS, and sleep deprivation could inhibit the activity of proteasome, lead to the dysfunction of E3 ubiquitin ligase, and then aggravate neuronal damage (Musiek and Holtzman, 2016)

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[DOI] [PubMed] [Google Scholar] 395.Wu WJ