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Mitochondrial ferritin has also been upregulated in the brain of mice with ischemic stroke upon FPN1 upregulation to attenuate ferroptosis and achieve neuroprotective effects (Wang P
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479,481,482 Currently, nivolumab, pembrolizumab, tislelizumab, atezolizumab, durvalumab, and avelumab have been approved for clinical use in the treatment of melanoma, NSCLC, etc