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This signaling activation results in the translocation of class II HDAC from the nucleus to cytosol, subsequently activating Mef2 and Mef2-dependent genes, as well as transcriptional factors regulating type 1 slow-twitch fibers

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This dose is 11 and 22 times, in rats and rabbits, respectively, the maximum recommended human dose (MRHD) of 400 mg/day in adults on a mg/m 2basis