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Irreversible inhibition of mitochondrial complex I by benzothiazine-3-carboxylic acid (DHBT-1): A putative nigral endotoxin of relevance to Parkinson’s disease

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At this moment, although regulatory clarity on postbiotics is developing, because they are chemically defined metabolites rather than live organisms, they are likely to follow a pathway similar to that of small molecule active pharmaceutical ingredients, which involves rigorous impurity profiling, stability, dose-range toxicology, and local tolerability studies, among other considerations