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🔬 Comparing Saline Types 📚 Clinical Evidence for Bacteriostatic Saline in Aesthetic Medicine ✅ Less Pain at Injection Sites A 2022 study published in Eye (Nature) reported a 32–60% reduction in injection site pain when Botox was reconstituted with bacteriostatic saline compared to preservative-free saline ¹

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When these vessels bleed into surrounding tissue, blood pools beneath the skin and appears as a bruise—medically called a hematoma